Assay Detail
Binding
CHEMBL687546
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Inhibition of human gelatinase B, MMP9
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.90 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439944 | — | — | 1 | 8.62 |
| CHEMBL73763 | — | — | 1 | 8.55 |
| CHEMBL74670 | — | — | 1 | 8.37 |
| CHEMBL306412 | — | — | 1 | 7.98 |
| CHEMBL307192 | — | — | 1 | 7.23 |
| CHEMBL305729 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439944 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL73763 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL74670 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL306412 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL307192 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL305729 | — | IC50 | = | 237.0 | nM | 6.62 |