Assay Detail
Functional
CHEMBL687608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of isoprenaline-induced relaxation of guinea pig tracheal chains, contracted with carbachol
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and beta-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 23 | 7.67 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304344 | — | — | 1 | 10.20 |
| CHEMBL69635 | — | — | 1 | 8.91 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.47 |
| CHEMBL419994 | — | — | 1 | 8.47 |
| CHEMBL67151 | — | — | 1 | 8.15 |
| CHEMBL67096 | TOLIPROLOL | 2.0 | 1 | 7.94 |
| CHEMBL68945 | — | — | 1 | 7.86 |
| CHEMBL7154 | — | — | 1 | 7.86 |
| CHEMBL302339 | — | — | 1 | 7.81 |
| CHEMBL68419 | — | — | 1 | 7.78 |
| CHEMBL66324 | — | — | 1 | 7.60 |
| CHEMBL66702 | — | — | 1 | 7.47 |
| CHEMBL67631 | — | — | 1 | 7.32 |
| CHEMBL63582 | — | — | 1 | 7.10 |
| CHEMBL66384 | — | — | 1 | 7.09 |
| CHEMBL66724 | — | — | 1 | 6.95 |
| CHEMBL66449 | — | — | 1 | 6.94 |
| CHEMBL302935 | — | — | 1 | 6.92 |
| CHEMBL66662 | — | — | 1 | 6.65 |
| CHEMBL66331 | — | — | 1 | 5.96 |
| CHEMBL68996 | — | — | 1 | - |
| CHEMBL67331 | — | — | 1 | - |
| CHEMBL304725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304344 | — | Kd | = | 0.0631 | nM | 10.20 |
| CHEMBL69635 | — | Kd | = | 1.23 | nM | 8.91 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 3.388 | nM | 8.47 |
| CHEMBL419994 | — | Kd | = | 3.388 | nM | 8.47 |
| CHEMBL67151 | — | Kd | = | 7.079 | nM | 8.15 |
| CHEMBL67096 | TOLIPROLOL | Kd | = | 11.48 | nM | 7.94 |
| CHEMBL68945 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL7154 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL302339 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL68419 | — | Kd | = | 16.6 | nM | 7.78 |
| CHEMBL66324 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL66702 | — | Kd | = | 33.88 | nM | 7.47 |
| CHEMBL67631 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL63582 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL66384 | — | Kd | = | 81.28 | nM | 7.09 |
| CHEMBL66724 | — | Kd | = | 112.2 | nM | 6.95 |
| CHEMBL66449 | — | Kd | = | 114.82 | nM | 6.94 |
| CHEMBL302935 | — | Kd | = | 120.23 | nM | 6.92 |
| CHEMBL66662 | — | Kd | = | 223.87 | nM | 6.65 |
| CHEMBL66331 | — | Kd | = | 1096.48 | nM | 5.96 |
| CHEMBL68996 | — | Kd | > | 125.89 | nM | - |
| CHEMBL67331 | — | Kd | > | 75.86 | nM | - |
| CHEMBL304725 | — | Kd | > | 85.11 | nM | - |