Assay Detail
Functional
CHEMBL687676
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Antiproliferative activity against human HT1080 fibrosarcoma cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.44 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123626 | — | — | 1 | 6.51 |
| CHEMBL124650 | — | — | 1 | 6.18 |
| CHEMBL126274 | — | — | 1 | 5.88 |
| CHEMBL435415 | — | — | 1 | 5.70 |
| CHEMBL126273 | — | — | 1 | 5.62 |
| CHEMBL340885 | — | — | 1 | 5.62 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.62 |
| CHEMBL124282 | — | — | 1 | 5.44 |
| CHEMBL124593 | — | — | 1 | 5.29 |
| CHEMBL124909 | — | — | 1 | 5.29 |
| CHEMBL340835 | — | — | 1 | 5.25 |
| CHEMBL339720 | — | — | 1 | 5.11 |
| CHEMBL127846 | — | — | 1 | 5.08 |
| CHEMBL125042 | — | — | 1 | 5.00 |
| CHEMBL339796 | — | — | 1 | 4.82 |
| CHEMBL123905 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123626 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL124650 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL126274 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL435415 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL126273 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL340885 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL124282 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL124593 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL124909 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL340835 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL339720 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL127846 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL125042 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL339796 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL123905 | — | IC50 | = | 27000.0 | nM | 4.57 |