Assay Detail
Functional
CHEMBL687679
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Concentration required for the antiproliferation of Human HT1080 fibrosarcoma cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.89 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329977 | — | — | 1 | 6.60 |
| CHEMBL328819 | — | — | 1 | 6.40 |
| CHEMBL317614 | — | — | 1 | 6.28 |
| CHEMBL317734 | — | — | 1 | 5.82 |
| CHEMBL98748 | — | — | 1 | 5.64 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.62 |
| CHEMBL98428 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329977 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL328819 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL317614 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL317734 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL98748 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL98428 | — | IC50 | = | 14000.0 | nM | 4.85 |