Assay Detail
Functional
CHEMBL687767
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Effective concentration against monocytes of HL-60 cells growth inhibition
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417692 | — | — | 1 | 8.30 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 8.30 |
| CHEMBL267144 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417692 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL27266 | INDOLACTUM | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL267144 | — | EC50 | > | 1000.0 | nM | - |