Assay Detail
Functional
CHEMBL687768
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Transglutaminase activity in HL-60 cdm-1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.20 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.70 |
| CHEMBL91718 | — | — | 1 | 8.30 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.30 |
| CHEMBL32505 | — | — | 1 | 8.00 |
| CHEMBL93628 | — | — | 1 | 7.70 |
| CHEMBL275311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL91718 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL38 | TRETINOIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL32505 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL93628 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL275311 | — | EC50 | > | 1000.0 | nM | - |