Assay Detail
Functional
CHEMBL688075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to reduce cell number (HL-60 human promyelocytic leukemia cell line) on day 7 by 50%
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.85 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33575 | — | — | 1 | 6.07 |
| CHEMBL284134 | — | — | 1 | 5.82 |
| CHEMBL433239 | — | — | 1 | 5.82 |
| CHEMBL287857 | — | — | 1 | 5.80 |
| CHEMBL29426 | — | — | 1 | 5.72 |
| CHEMBL286140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33575 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL284134 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL433239 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL287857 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL29426 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL286140 | — | IC50 | > | 300000.0 | nM | - |