Assay Detail
Functional
CHEMBL688076
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Cytostatic activity against HL-60 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.29 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 4.96 |
| CHEMBL424315 | — | — | 1 | 4.26 |
| CHEMBL344122 | — | — | 1 | 4.14 |
| CHEMBL147845 | — | — | 1 | 4.14 |
| CHEMBL357015 | — | — | 1 | 4.13 |
| CHEMBL144058 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL424315 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL344122 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL147845 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL357015 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL144058 | — | IC50 | = | 75000.0 | nM | 4.12 |