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Assay Detail

CHEMBL688085

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity in HL-60 (human leukemia) cell line.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Expert

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Design of antineoplastic agents based on the "2-phenylnaphthalene-type" structural pattern. 4. Synthesis and biological activity of 2-chloro-3-(substituted phenoxy)-1, 4-naphthoquinones and related 5,8-dihydroxy-1,4-naphthoquinones.
Chang HX, Chou TC, Savaraj N, Liu LF, Yu C, Cheng CC.
J Med Chem (1999) 42 : 405 -408
PubMed 9986711 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.50 7.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL310396 1 7.31
CHEMBL130836 1 7.17
CHEMBL130862 1 7.16
CHEMBL132613 1 6.92
CHEMBL422982 1 6.89
CHEMBL335159 1 6.80
CHEMBL131549 1 6.80
CHEMBL133181 1 6.70
CHEMBL130001 1 6.70
CHEMBL130408 1 6.66
CHEMBL133389 1 6.66
CHEMBL131037 1 6.66
CHEMBL129941 1 6.60
CHEMBL133394 1 6.41
CHEMBL132829 1 6.36
CHEMBL130385 1 6.30
CHEMBL130758 1 6.00
CHEMBL336777 1 4.84
CHEMBL336075 1 4.52
CHEMBL131038 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL310396 IC50 = 49.0 nM 7.31
CHEMBL130836 IC50 = 67.0 nM 7.17
CHEMBL130862 IC50 = 70.0 nM 7.16
CHEMBL132613 IC50 = 120.0 nM 6.92
CHEMBL422982 IC50 = 130.0 nM 6.89
CHEMBL335159 IC50 = 160.0 nM 6.80
CHEMBL131549 IC50 = 160.0 nM 6.80
CHEMBL133181 IC50 = 200.0 nM 6.70
CHEMBL130001 IC50 = 200.0 nM 6.70
CHEMBL130408 IC50 = 220.0 nM 6.66
CHEMBL133389 IC50 = 220.0 nM 6.66
CHEMBL131037 IC50 = 220.0 nM 6.66
CHEMBL129941 IC50 = 250.0 nM 6.60
CHEMBL133394 IC50 = 390.0 nM 6.41
CHEMBL132829 IC50 = 440.0 nM 6.36
CHEMBL130385 IC50 = 500.0 nM 6.30
CHEMBL130758 IC50 = 1000.0 nM 6.00
CHEMBL336777 IC50 = 14500.0 nM 4.84
CHEMBL336075 IC50 = 30000.0 nM 4.52
CHEMBL131038 IC50 = 127900.0 nM -