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Assay Detail

CHEMBL688172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LTC4-induced contraction of isolated guinea pig ileum.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cysteinyl leukotriene receptor (CHEMBL2094254)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Quantitative structure-activity relationships of benzamide derivatives for anti-leukotriene activities.
Goto S, Guo Z, Futatsuishi Y, Hori H, Taira Z, Terada H.
J Med Chem (1992) 35 : 2440 -2445
PubMed 1619618 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.77 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL83797 1 9.30
CHEMBL312105 1 9.07
CHEMBL81565 1 8.38
CHEMBL83447 1 8.26
CHEMBL311891 1 8.26
CHEMBL312051 1 8.15
CHEMBL312090 1 8.13
CHEMBL80993 1 8.05
CHEMBL82033 1 7.89
CHEMBL311759 1 7.85
CHEMBL78974 1 7.82
CHEMBL81585 1 7.70
CHEMBL81988 1 7.15
CHEMBL311277 1 7.00
CHEMBL81487 1 7.00
CHEMBL81065 1 6.80
CHEMBL78547 1 6.68
CHEMBL312283 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL83797 IC50 = 0.5012 nM 9.30
CHEMBL312105 IC50 = 0.8511 nM 9.07
CHEMBL81565 IC50 = 4.169 nM 8.38
CHEMBL83447 IC50 = 5.495 nM 8.26
CHEMBL311891 IC50 = 5.495 nM 8.26
CHEMBL312051 IC50 = 7.079 nM 8.15
CHEMBL312090 IC50 = 7.413 nM 8.13
CHEMBL80993 IC50 = 8.913 nM 8.05
CHEMBL82033 IC50 = 12.88 nM 7.89
CHEMBL311759 IC50 = 14.13 nM 7.85
CHEMBL78974 IC50 = 15.14 nM 7.82
CHEMBL81585 IC50 = 19.95 nM 7.70
CHEMBL81988 IC50 = 70.79 nM 7.15
CHEMBL311277 IC50 = 100.0 nM 7.00
CHEMBL81487 IC50 = 100.0 nM 7.00
CHEMBL81065 IC50 = 158.49 nM 6.80
CHEMBL78547 IC50 = 208.93 nM 6.68
CHEMBL312283 IC50 = 501.19 nM 6.30