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Assay Detail

CHEMBL688285

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Gastric mucosa
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Potassium-transporting ATPase (CHEMBL2095228) ↗
Type PROTEIN COMPLEX
Organism Sus scrofa

Publication

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6-tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors.
Yamada M, Yura T, Morimoto M, Harada T, Yamada K, Honma Y, Kinoshita M, Sugiura M.
J Med Chem (1996) 39 : 596 -604
PubMed 8558532 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 4.70 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL155575 — — 1 5.60
CHEMBL350914 — — 1 5.58
CHEMBL346819 — — 1 5.47
CHEMBL1503 OMEPRAZOLE 4.0 1 5.42
CHEMBL345354 — — 1 5.32
CHEMBL347442 — — 1 5.26
CHEMBL440543 — — 1 5.24
CHEMBL347598 — — 1 5.22
CHEMBL157751 — — 1 5.17
CHEMBL351335 — — 1 5.16
CHEMBL158181 — — 1 5.13
CHEMBL155435 — — 1 5.12
CHEMBL348541 — — 1 5.12
CHEMBL154784 — — 1 4.96
CHEMBL155660 — — 1 4.96
CHEMBL346917 — — 1 4.92
CHEMBL157861 — — 1 4.92
CHEMBL346293 — — 1 4.92
CHEMBL156817 — — 1 4.89
CHEMBL158292 — — 1 4.89
CHEMBL158022 — — 1 4.85
CHEMBL347485 — — 1 4.85
CHEMBL345427 — — 1 4.80
CHEMBL347649 — — 1 4.80
CHEMBL156223 — — 1 4.75
CHEMBL155083 — — 1 4.70
CHEMBL345658 — — 1 4.57
CHEMBL158003 — — 1 4.55
CHEMBL156341 — — 1 4.51
CHEMBL348081 — — 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL155575 — IC50 = 2500.0 nM 5.60
CHEMBL350914 — IC50 = 2600.0 nM 5.58
CHEMBL346819 — IC50 = 3400.0 nM 5.47
CHEMBL1503 OMEPRAZOLE IC50 = 3800.0 nM 5.42
CHEMBL345354 — IC50 = 4800.0 nM 5.32
CHEMBL347442 — IC50 = 5500.0 nM 5.26
CHEMBL440543 — IC50 = 5700.0 nM 5.24
CHEMBL347598 — IC50 = 6000.0 nM 5.22
CHEMBL157751 — IC50 = 6800.0 nM 5.17
CHEMBL351335 — IC50 = 7000.0 nM 5.16
CHEMBL158181 — IC50 = 7400.0 nM 5.13
CHEMBL155435 — IC50 = 7500.0 nM 5.12
CHEMBL348541 — IC50 = 7500.0 nM 5.12
CHEMBL155660 — IC50 = 11000.0 nM 4.96
CHEMBL154784 — IC50 = 11000.0 nM 4.96
CHEMBL346917 — IC50 = 12000.0 nM 4.92
CHEMBL346293 — IC50 = 12000.0 nM 4.92
CHEMBL157861 — IC50 = 12000.0 nM 4.92
CHEMBL156817 — IC50 = 13000.0 nM 4.89
CHEMBL158292 — IC50 = 13000.0 nM 4.89
CHEMBL158022 — IC50 = 14000.0 nM 4.85
CHEMBL347485 — IC50 = 14000.0 nM 4.85
CHEMBL345427 — IC50 = 16000.0 nM 4.80
CHEMBL347649 — IC50 = 16000.0 nM 4.80
CHEMBL156223 — IC50 = 18000.0 nM 4.75
CHEMBL155083 — IC50 = 20000.0 nM 4.70
CHEMBL345658 — IC50 = 27000.0 nM 4.57
CHEMBL158003 — IC50 = 28000.0 nM 4.55
CHEMBL156341 — IC50 = 31000.0 nM 4.51
CHEMBL348081 — IC50 = 32000.0 nM 4.50
CHEMBL347946 — IC50 = 32000.0 nM 4.50
CHEMBL351764 — IC50 = 32000.0 nM 4.50
CHEMBL154029 — IC50 = 33000.0 nM 4.48
CHEMBL346998 — IC50 = 33000.0 nM 4.48
CHEMBL154737 — IC50 = 35000.0 nM 4.46
CHEMBL154423 — IC50 = 36000.0 nM 4.44
CHEMBL155019 — IC50 = 43000.0 nM 4.37
CHEMBL157099 — IC50 = 44000.0 nM 4.36
CHEMBL157726 — IC50 = 44000.0 nM 4.36
CHEMBL154360 — IC50 = 46000.0 nM 4.34
CHEMBL421989 — IC50 = 50000.0 nM 4.30
CHEMBL350014 — IC50 = 55000.0 nM 4.26
CHEMBL157835 — IC50 = 59000.0 nM 4.23
CHEMBL348090 — IC50 = 60000.0 nM 4.22
CHEMBL158247 — IC50 = 68000.0 nM 4.17
CHEMBL155543 — IC50 = 68000.0 nM 4.17
CHEMBL347265 — IC50 = 81000.0 nM 4.09
CHEMBL345766 — IC50 = 95000.0 nM 4.02
CHEMBL347483 — IC50 = 98000.0 nM 4.01
CHEMBL348886 — IC50 = 100000.0 nM 4.00