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Assay Detail

CHEMBL688290

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Binding
Inhibition of K+ stimulated gastric ATPase activity
ChEMBL ↗
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Stomach
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Potassium-transporting ATPase (CHEMBL2095228) ↗
Type PROTEIN COMPLEX
Organism Sus scrofa

Publication

Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines.
Ife RJ, Brown TH, Blurton P, Keeling DJ, Leach CA, Meeson ML, Parsons ME, Theobald CJ.
J Med Chem (1995) 38 : 2763 -2773
PubMed 7629814 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 66 6.56 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96835 — — 1 7.75
CHEMBL92087 — — 1 7.72
CHEMBL315880 — — 1 7.72
CHEMBL92833 — — 1 7.68
CHEMBL330495 — — 1 7.68
CHEMBL92757 — — 1 7.66
CHEMBL330247 — — 1 7.62
CHEMBL92510 — — 1 7.55
CHEMBL420621 — — 1 7.50
CHEMBL421746 — — 1 7.47
CHEMBL330283 — — 1 7.47
CHEMBL94378 — — 1 7.46
CHEMBL93756 — — 1 7.44
CHEMBL327983 — — 1 7.39
CHEMBL92756 — — 1 7.38
CHEMBL329852 — — 1 7.34
CHEMBL91804 — — 1 7.30
CHEMBL330222 — — 1 7.19
CHEMBL92968 — — 1 7.17
CHEMBL91984 — — 1 7.13
CHEMBL421554 — — 1 7.10
CHEMBL93369 — — 1 7.02
CHEMBL96619 — — 1 7.00
CHEMBL328372 — — 1 7.00
CHEMBL95046 — — 1 6.92
CHEMBL96324 — — 1 6.89
CHEMBL92888 — — 1 6.89
CHEMBL96456 — — 1 6.89
CHEMBL330716 — — 1 6.85
CHEMBL432001 — — 1 6.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96835 — IC50 = 18.0 nM 7.75
CHEMBL92087 — IC50 = 19.0 nM 7.72
CHEMBL315880 — IC50 = 19.0 nM 7.72
CHEMBL92833 — IC50 = 21.0 nM 7.68
CHEMBL330495 — IC50 = 21.0 nM 7.68
CHEMBL92757 — IC50 = 22.0 nM 7.66
CHEMBL330247 — IC50 = 24.0 nM 7.62
CHEMBL92510 — IC50 = 28.0 nM 7.55
CHEMBL420621 — IC50 = 32.0 nM 7.50
CHEMBL421746 — IC50 = 34.0 nM 7.47
CHEMBL330283 — IC50 = 34.0 nM 7.47
CHEMBL94378 — IC50 = 35.0 nM 7.46
CHEMBL93756 — IC50 = 36.0 nM 7.44
CHEMBL327983 — IC50 = 41.0 nM 7.39
CHEMBL92756 — IC50 = 42.0 nM 7.38
CHEMBL329852 — IC50 = 46.0 nM 7.34
CHEMBL91804 — IC50 = 50.0 nM 7.30
CHEMBL330222 — IC50 = 65.0 nM 7.19
CHEMBL92968 — IC50 = 67.0 nM 7.17
CHEMBL91984 — IC50 = 74.0 nM 7.13
CHEMBL421554 — IC50 = 80.0 nM 7.10
CHEMBL93369 — IC50 = 95.0 nM 7.02
CHEMBL96619 — IC50 = 100.0 nM 7.00
CHEMBL328372 — IC50 = 100.0 nM 7.00
CHEMBL95046 — IC50 = 120.0 nM 6.92
CHEMBL96324 — IC50 = 130.0 nM 6.89
CHEMBL96456 — IC50 = 130.0 nM 6.89
CHEMBL92888 — IC50 = 130.0 nM 6.89
CHEMBL330716 — IC50 = 140.0 nM 6.85
CHEMBL432001 — IC50 = 170.0 nM 6.77
CHEMBL54511 — IC50 = 180.0 nM 6.75
CHEMBL327199 — IC50 = 240.0 nM 6.62
CHEMBL92962 — IC50 = 250.0 nM 6.60
CHEMBL316926 — IC50 = 260.0 nM 6.58
CHEMBL96590 — IC50 = 300.0 nM 6.52
CHEMBL96272 — IC50 = 320.0 nM 6.50
CHEMBL92525 — IC50 = 340.0 nM 6.47
CHEMBL92764 — IC50 = 360.0 nM 6.44
CHEMBL330691 — IC50 = 370.0 nM 6.43
CHEMBL92850 — IC50 = 510.0 nM 6.29
CHEMBL95151 — IC50 = 510.0 nM 6.29
CHEMBL92450 — IC50 = 510.0 nM 6.29
CHEMBL328578 — IC50 = 590.0 nM 6.23
CHEMBL96287 — IC50 = 600.0 nM 6.22
CHEMBL92867 — IC50 = 640.0 nM 6.19
CHEMBL92137 — IC50 = 810.0 nM 6.09
CHEMBL323131 — IC50 = 940.0 nM 6.03
CHEMBL94374 — IC50 = 1070.0 nM 5.97
CHEMBL318271 — IC50 = 1100.0 nM 5.96
CHEMBL96790 — IC50 = 1200.0 nM 5.92