Assay Detail
Functional
CHEMBL688348
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In vitro cytotoxicity against human colon carcinoma (HCT116) tumor cell line
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.55 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293834 | — | — | 1 | 7.16 |
| CHEMBL416673 | — | — | 1 | 6.86 |
| CHEMBL61102 | — | — | 1 | 6.43 |
| CHEMBL302389 | — | — | 1 | 6.28 |
| CHEMBL65633 | — | — | 1 | 6.02 |
| CHEMBL63079 | — | — | 1 | - |
| CHEMBL64186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293834 | — | IC50 | = | 68.75 | nM | 7.16 |
| CHEMBL416673 | — | IC50 | = | 139.6 | nM | 6.86 |
| CHEMBL61102 | — | IC50 | = | 367.9 | nM | 6.43 |
| CHEMBL302389 | — | IC50 | = | 526.3 | nM | 6.28 |
| CHEMBL65633 | — | IC50 | = | 950.3 | nM | 6.02 |
| CHEMBL63079 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL64186 | — | IC50 | > | 10000.0 | nM | - |