Assay Detail
Functional
CHEMBL688354
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Inhibitory activity against HCT116 cells after 24 hr cell growth
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.92 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441018 | CRYPTOPHYCIN A | — | 1 | 10.57 |
| CHEMBL264224 | ARENASTATIN A | — | 1 | 9.54 |
| CHEMBL165020 | — | — | 1 | 8.96 |
| CHEMBL166221 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441018 | CRYPTOPHYCIN A | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL264224 | ARENASTATIN A | IC50 | = | 0.285 | nM | 9.54 |
| CHEMBL165020 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL166221 | — | IC50 | = | 253.0 | nM | 6.60 |