Assay Detail
Functional
CHEMBL688519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the antiviral activity against compound resistant virus isolate M184I with amino acid changes in the HIV-1 reverse transcriptase (RT)
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.17 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL269090 | — | — | 2 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL269090 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL269090 | — | EC50 | = | 60470.0 | nM | 4.22 |