Assay Detail
Functional
CHEMBL688526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the antiviral activity against resistant virus isolate IIIB with amino acid changes in the HIV-1 reverse transcriptase (RT)
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.79 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.05 |
| CHEMBL269090 | — | — | 2 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL269090 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL269090 | — | EC50 | = | 1470.0 | nM | 5.83 |