Assay Detail
Functional
CHEMBL688532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to inhibit HIV-1 replication in MT-4 cell line
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
S-acyl-2-thioethyl phosphoramidate diester derivatives as mononucleotide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.60 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.77 |
| CHEMBL343639 | — | — | 1 | 7.28 |
| CHEMBL141296 | — | — | 1 | 6.89 |
| CHEMBL298640 | — | — | 1 | 6.89 |
| CHEMBL335818 | — | — | 1 | 6.66 |
| CHEMBL342234 | — | — | 1 | 6.60 |
| CHEMBL343386 | — | — | 1 | 6.47 |
| CHEMBL2311110 | — | — | 1 | 6.47 |
| CHEMBL141480 | — | — | 1 | 6.40 |
| CHEMBL141220 | — | — | 1 | 6.38 |
| CHEMBL141119 | — | — | 1 | 6.35 |
| CHEMBL143831 | — | — | 1 | 6.35 |
| CHEMBL140698 | — | — | 1 | 6.27 |
| CHEMBL52484 | — | — | 1 | 6.16 |
| CHEMBL335368 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL343639 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL141296 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL298640 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL335818 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL342234 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL343386 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2311110 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL141480 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL141220 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL141119 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL143831 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL140698 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL52484 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL335368 | — | EC50 | = | 740.0 | nM | 6.13 |