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Assay Detail

CHEMBL688764

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Functional
Inhibitory activity against HCT116 human colon cell growth
ChEMBL ↗
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Expert

Target

HCT-116 (CHEMBL394) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
Remiszewski SW, Sambucetti LC, Bair KW, Bontempo J, Cesarz D, Chandramouli N, Chen R, Cheung M, Cornell-Kennon S, Dean K, Diamantidis G, France D, Green MA, Howell KL, Kashi R, Kwon P, Lassota P, Martin MS, Mou Y, Perez LB, Sharma S, Smith T, Sorensen E, Taplin F, Trogani N, Versace R, Walker H, Weltchek-Engler S, Wood A, Wu A, Atadja P.
J Med Chem (2003) 46 : 4609 -4624
PubMed 14521422 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 7.27 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2000089 TRAPOXIN B — 1 8.70
CHEMBL357231 — — 1 8.22
CHEMBL142992 — — 1 8.22
CHEMBL356066 DACINOSTAT 2.0 1 8.00
CHEMBL341601 — — 1 8.00
CHEMBL343557 — — 1 8.00
CHEMBL99 TRICHOSTATIN 1.0 1 7.89
CHEMBL140566 — — 1 7.82
CHEMBL143329 — — 1 7.82
CHEMBL143255 — — 1 7.77
CHEMBL140088 — — 1 7.70
CHEMBL141236 — — 1 7.52
CHEMBL143283 — — 1 7.52
CHEMBL141502 — — 1 7.52
CHEMBL344227 — — 1 7.52
CHEMBL140013 — — 1 7.52
CHEMBL140014 — — 1 7.52
CHEMBL141087 — — 1 7.40
CHEMBL142120 — — 1 7.40
CHEMBL348256 — — 1 7.40
CHEMBL358059 — — 1 7.40
CHEMBL139663 — — 1 7.40
CHEMBL335812 — — 1 7.30
CHEMBL343068 — — 1 7.30
CHEMBL343823 — — 1 7.30
CHEMBL342474 — — 1 7.30
CHEMBL139836 — — 1 7.00
CHEMBL140811 — — 1 6.96
CHEMBL421934 — — 1 6.92
CHEMBL140900 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2000089 TRAPOXIN B IC50 = 2.0 nM 8.70
CHEMBL357231 — IC50 = 6.0 nM 8.22
CHEMBL142992 — IC50 = 6.0 nM 8.22
CHEMBL356066 DACINOSTAT IC50 = 10.0 nM 8.00
CHEMBL341601 — IC50 = 10.0 nM 8.00
CHEMBL343557 — IC50 = 10.0 nM 8.00
CHEMBL99 TRICHOSTATIN IC50 = 13.0 nM 7.89
CHEMBL140566 — IC50 = 15.0 nM 7.82
CHEMBL143329 — IC50 = 15.0 nM 7.82
CHEMBL143255 — IC50 = 17.0 nM 7.77
CHEMBL140088 — IC50 = 20.0 nM 7.70
CHEMBL140014 — IC50 = 30.0 nM 7.52
CHEMBL140013 — IC50 = 30.0 nM 7.52
CHEMBL344227 — IC50 = 30.0 nM 7.52
CHEMBL141502 — IC50 = 30.0 nM 7.52
CHEMBL141236 — IC50 = 30.0 nM 7.52
CHEMBL143283 — IC50 = 30.0 nM 7.52
CHEMBL139663 — IC50 = 40.0 nM 7.40
CHEMBL358059 — IC50 = 40.0 nM 7.40
CHEMBL142120 — IC50 = 40.0 nM 7.40
CHEMBL141087 — IC50 = 40.0 nM 7.40
CHEMBL348256 — IC50 = 40.0 nM 7.40
CHEMBL335812 — IC50 = 50.0 nM 7.30
CHEMBL343068 — IC50 = 50.0 nM 7.30
CHEMBL343823 — IC50 = 50.0 nM 7.30
CHEMBL342474 — IC50 = 50.0 nM 7.30
CHEMBL139836 — IC50 = 100.0 nM 7.00
CHEMBL140811 — IC50 = 110.0 nM 6.96
CHEMBL421934 — IC50 = 120.0 nM 6.92
CHEMBL140530 — IC50 = 160.0 nM 6.80
CHEMBL343091 — IC50 = 160.0 nM 6.80
CHEMBL140899 — IC50 = 160.0 nM 6.80
CHEMBL140900 — IC50 = 160.0 nM 6.80
CHEMBL140505 — IC50 = 170.0 nM 6.77
CHEMBL142931 — IC50 = 200.0 nM 6.70
CHEMBL341826 — IC50 = 420.0 nM 6.38
CHEMBL336674 — IC50 = 430.0 nM 6.37
CHEMBL143179 — IC50 = 480.0 nM 6.32
CHEMBL357268 — IC50 = 670.0 nM 6.17
CHEMBL143497 — IC50 = 740.0 nM 6.13
CHEMBL98 VORINOSTAT IC50 = 1930.0 nM 5.71