Assay Detail
Functional
CHEMBL688769
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Concentration which produces 50% inhibition of growth of human colon tumor HCT 116
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Combretoxazolones: synthesis, cytotoxicity and antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.10 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.05 |
| CHEMBL101859 | — | — | 1 | 8.77 |
| CHEMBL106389 | — | — | 1 | 8.49 |
| CHEMBL321541 | — | — | 1 | 8.43 |
| CHEMBL450580 | — | — | 1 | 8.31 |
| CHEMBL432002 | — | — | 1 | 8.21 |
| CHEMBL323781 | — | — | 1 | 7.96 |
| CHEMBL104148 | — | — | 1 | 7.95 |
| CHEMBL317190 | — | — | 1 | 7.66 |
| CHEMBL107801 | — | — | 1 | 7.24 |
| CHEMBL321299 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL101859 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL106389 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL321541 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL450580 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL432002 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL323781 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL104148 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL317190 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL107801 | — | IC50 | = | 57.4 | nM | 7.24 |
| CHEMBL321299 | — | IC50 | = | 101.1 | nM | 7.00 |