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Assay Detail

CHEMBL688961

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV-1 IIIB in H9 (human leukemia) cells.
22
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type H9
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors
Schwartz TM, Bundy GL, Strohbach JW, Thaisrivongs S, Johnson PD, Skulnick HI, Tomich PK, Lynn JC, Chong KT, Hinshaw RR, Raub TJ, Padbury GE, Toth LN
Bioorg Med Chem Lett (1997) 7 : 399 -402
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.15 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2062136 1 5.82
CHEMBL277309 1 5.68
CHEMBL80882 1 5.66
CHEMBL279580 1 5.44
CHEMBL16400 1 5.30
CHEMBL127219 1 5.11
CHEMBL129802 1 5.00
CHEMBL340638 1 4.92
CHEMBL131064 1 4.84
CHEMBL131821 1 4.70
CHEMBL338756 1 4.69
CHEMBL131128 1 4.69
CHEMBL132275 1 -
CHEMBL131317 1 -
CHEMBL16711 1 -
CHEMBL16636 1 -
CHEMBL130184 2 -
CHEMBL131658 1 -
CHEMBL128629 2 -
CHEMBL131395 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2062136 IC50 = 1500.0 nM 5.82
CHEMBL277309 IC50 = 2100.0 nM 5.68
CHEMBL80882 IC50 = 2200.0 nM 5.66
CHEMBL279580 IC50 = 3600.0 nM 5.44
CHEMBL16400 IC50 = 5000.0 nM 5.30
CHEMBL127219 IC50 = 7700.0 nM 5.11
CHEMBL129802 IC50 = 10000.0 nM 5.00
CHEMBL340638 IC50 = 12000.0 nM 4.92
CHEMBL131064 IC50 = 14500.0 nM 4.84
CHEMBL131821 IC50 = 19800.0 nM 4.70
CHEMBL131128 IC50 = 20500.0 nM 4.69
CHEMBL338756 IC50 = 20400.0 nM 4.69
CHEMBL132275 IC50 > 3000.0 nM -
CHEMBL131317 IC50 > 30000.0 nM -
CHEMBL16711 IC50 > 10000.0 nM -
CHEMBL16636 IC50 < 1000.0 nM -
CHEMBL130184 IC50 < 3000.0 nM -
CHEMBL130184 IC50 > 1000.0 nM -
CHEMBL131658 IC50 > 30000.0 nM -
CHEMBL128629 IC50 < 3000.0 nM -
CHEMBL128629 IC50 > 1000.0 nM -
CHEMBL131395 IC50 > 30000.0 nM -