Assay Detail
Functional
CHEMBL689145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration (anti-HIV activity) required to reduce HIV-1 induced cytopathic effect by 50% in MT-4 cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.31 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356190 | — | — | 1 | 7.52 |
| CHEMBL150081 | — | — | 1 | 7.38 |
| CHEMBL48427 | — | — | 1 | 7.36 |
| CHEMBL359315 | — | — | 1 | 7.28 |
| CHEMBL150025 | — | — | 1 | 7.23 |
| CHEMBL150662 | — | — | 1 | 7.19 |
| CHEMBL296589 | — | — | 1 | 7.09 |
| CHEMBL358883 | — | — | 1 | 7.05 |
| CHEMBL151152 | — | — | 1 | 7.00 |
| CHEMBL300179 | — | — | 1 | 6.83 |
| CHEMBL50805 | — | — | 1 | 6.75 |
| CHEMBL50019 | — | — | 1 | 6.61 |
| CHEMBL150255 | — | — | 1 | 6.57 |
| CHEMBL434851 | — | — | 1 | 6.56 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 6.45 |
| CHEMBL299364 | — | — | 1 | 6.40 |
| CHEMBL50948 | — | — | 1 | 6.07 |
| CHEMBL150379 | — | — | 1 | 5.91 |
| CHEMBL346225 | — | — | 1 | 5.85 |
| CHEMBL357261 | — | — | 1 | 5.82 |
| CHEMBL422322 | — | — | 1 | 5.75 |
| CHEMBL149913 | — | — | 1 | 5.67 |
| CHEMBL357713 | — | — | 1 | 5.31 |
| CHEMBL53540 | — | — | 1 | 5.29 |
| CHEMBL150149 | — | — | 1 | 5.14 |
| CHEMBL50428 | — | — | 1 | 4.27 |
| CHEMBL300859 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356190 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL150081 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL48427 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL359315 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL150025 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL150662 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL296589 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL358883 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL151152 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL300179 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL50805 | — | EC50 | = | 178.0 | nM | 6.75 |
| CHEMBL50019 | — | EC50 | = | 248.0 | nM | 6.61 |
| CHEMBL150255 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL434851 | — | EC50 | = | 278.0 | nM | 6.56 |
| CHEMBL625 | THIABENDAZOLE | EC50 | = | 352.0 | nM | 6.45 |
| CHEMBL299364 | — | EC50 | = | 401.0 | nM | 6.40 |
| CHEMBL50948 | — | EC50 | = | 855.0 | nM | 6.07 |
| CHEMBL150379 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL346225 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL357261 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL422322 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL149913 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL357713 | — | EC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL53540 | — | EC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL150149 | — | EC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL50428 | — | EC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL300859 | — | EC50 | = | 95100.0 | nM | 4.02 |