Assay Detail
Functional
CHEMBL689146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration (anti-HIV activity) required to reduce HIV-1 induced cytopathic effect by 50%in CEM cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.44 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356190 | — | — | 1 | 7.52 |
| CHEMBL359315 | — | — | 1 | 7.40 |
| CHEMBL150025 | — | — | 1 | 7.11 |
| CHEMBL151152 | — | — | 1 | 6.97 |
| CHEMBL358883 | — | — | 1 | 6.89 |
| CHEMBL150255 | — | — | 1 | 6.76 |
| CHEMBL434851 | — | — | 1 | 6.62 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 5.96 |
| CHEMBL357261 | — | — | 1 | 5.88 |
| CHEMBL346225 | — | — | 1 | 5.88 |
| CHEMBL422322 | — | — | 1 | 5.73 |
| CHEMBL357713 | — | — | 1 | 5.60 |
| CHEMBL150149 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356190 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL359315 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL150025 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL151152 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL358883 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL150255 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL434851 | — | EC50 | = | 242.0 | nM | 6.62 |
| CHEMBL625 | THIABENDAZOLE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL357261 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL346225 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL422322 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL357713 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL150149 | — | EC50 | = | 4130.0 | nM | 5.38 |