Assay Detail
Functional
CHEMBL689151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against HIV-1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.65 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL612054 | — | — | 1 | 6.23 |
| CHEMBL326531 | MANZAMINE | — | 1 | 5.38 |
| CHEMBL118640 | IRCINOL A | — | 1 | 5.37 |
| CHEMBL332054 | IRCINAL | — | 1 | 5.17 |
| CHEMBL399694 | MANZAMINE F | — | 1 | 5.14 |
| CHEMBL399493 | MANZAMINE E | — | 1 | 4.88 |
| CHEMBL332889 | 12,28-OXAMANZAMINE A | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL612054 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL326531 | MANZAMINE | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL118640 | IRCINOL A | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL332054 | IRCINAL | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL399694 | MANZAMINE F | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL399493 | MANZAMINE E | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL332889 | 12,28-OXAMANZAMINE A | EC50 | = | 22200.0 | nM | 4.65 |