Assay Detail
Functional
CHEMBL689286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (CHEMBL2111431) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.58 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116595 | — | — | 1 | 6.89 |
| CHEMBL326318 | — | — | 1 | 6.70 |
| CHEMBL326100 | — | — | 1 | 6.60 |
| CHEMBL118109 | — | — | 1 | 6.46 |
| CHEMBL119987 | — | — | 1 | 6.35 |
| CHEMBL119156 | — | — | 1 | 6.16 |
| CHEMBL432428 | — | — | 1 | 5.99 |
| CHEMBL118205 | — | — | 1 | 5.82 |
| CHEMBL419047 | — | — | 1 | 5.80 |
| CHEMBL333454 | — | — | 1 | 5.78 |
| CHEMBL324030 | — | — | 1 | 5.70 |
| CHEMBL122522 | — | — | 1 | 5.60 |
| CHEMBL119923 | — | — | 1 | 5.52 |
| CHEMBL115895 | — | — | 1 | 5.48 |
| CHEMBL330879 | — | — | 1 | 5.34 |
| CHEMBL116547 | — | — | 1 | 5.21 |
| CHEMBL331026 | — | — | 1 | 5.21 |
| CHEMBL333553 | — | — | 1 | 5.09 |
| CHEMBL115519 | — | — | 1 | 4.82 |
| CHEMBL326044 | — | — | 1 | 4.80 |
| CHEMBL334032 | — | — | 1 | 4.76 |
| CHEMBL116423 | — | — | 1 | 4.23 |
| CHEMBL120719 | — | — | 1 | 4.04 |
| CHEMBL118321 | — | — | 1 | - |
| CHEMBL120564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116595 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL326318 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL326100 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL118109 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL119987 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL119156 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL432428 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL118205 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL419047 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL333454 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL324030 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL122522 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL119923 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL115895 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL330879 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL116547 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL331026 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL333553 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL115519 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL326044 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL334032 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL116423 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL120719 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL118321 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL120564 | — | IC50 | = | 112000.0 | nM | - |