Assay Detail
Functional
CHEMBL689290
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Inhibition of HER-14 (human EGFR overexpressing NIH3T3) cell proliferation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.06 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116547 | — | — | 1 | 5.70 |
| CHEMBL419047 | — | — | 1 | 5.70 |
| CHEMBL432428 | — | — | 1 | 5.52 |
| CHEMBL115519 | — | — | 1 | 5.35 |
| CHEMBL118205 | — | — | 1 | 5.22 |
| CHEMBL122522 | — | — | 1 | 5.22 |
| CHEMBL326044 | — | — | 1 | 5.19 |
| CHEMBL115895 | — | — | 1 | 5.05 |
| CHEMBL330879 | — | — | 1 | 5.00 |
| CHEMBL326100 | — | — | 1 | 5.00 |
| CHEMBL333454 | — | — | 1 | 4.92 |
| CHEMBL326318 | — | — | 1 | 4.90 |
| CHEMBL116595 | — | — | 1 | 4.90 |
| CHEMBL119156 | — | — | 1 | 4.80 |
| CHEMBL119923 | — | — | 1 | 4.70 |
| CHEMBL331026 | — | — | 1 | 4.46 |
| CHEMBL118109 | — | — | 1 | 4.46 |
| CHEMBL120719 | — | — | 1 | - |
| CHEMBL118321 | — | — | 1 | - |
| CHEMBL119987 | — | — | 1 | - |
| CHEMBL324030 | — | — | 1 | - |
| CHEMBL333553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116547 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL419047 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL432428 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL115519 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL118205 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL122522 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL326044 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL115895 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL330879 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL326100 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL333454 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL326318 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL116595 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL119156 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL119923 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL331026 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL118109 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL120719 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118321 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119987 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL324030 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL333553 | — | IC50 | > | 50000.0 | nM | - |