Assay Detail
Functional
CHEMBL689291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER-14 (human EGFR overexpressing NIH3T3) cell proliferation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.86 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116423 | — | — | 1 | 4.89 |
| CHEMBL334032 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116423 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL334032 | — | IC50 | = | 15000.0 | nM | 4.82 |