Assay Detail
Functional
CHEMBL689298
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Antiproliferative activity determined by measuring the ability to block [3H]- thymidine uptake in HER-14 cells stimulated by EGF
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HER-14 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.13 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356324 | — | — | 1 | 5.70 |
| CHEMBL67535 | — | — | 1 | 5.52 |
| CHEMBL357400 | — | — | 1 | 5.52 |
| CHEMBL144778 | — | — | 1 | 5.40 |
| CHEMBL342792 | — | — | 1 | 5.40 |
| CHEMBL358746 | — | — | 1 | 5.30 |
| CHEMBL144760 | — | — | 1 | 5.30 |
| CHEMBL144589 | — | — | 1 | 5.30 |
| CHEMBL145209 | — | — | 1 | 5.24 |
| CHEMBL144159 | — | — | 1 | 5.22 |
| CHEMBL343887 | — | — | 1 | 5.21 |
| CHEMBL144402 | — | — | 1 | 5.16 |
| CHEMBL144770 | — | — | 1 | 5.14 |
| CHEMBL144842 | — | — | 1 | 5.05 |
| CHEMBL358494 | — | — | 1 | 5.00 |
| CHEMBL144908 | — | — | 1 | 5.00 |
| CHEMBL144791 | — | — | 1 | 4.96 |
| CHEMBL147880 | — | — | 1 | 4.69 |
| CHEMBL279138 | — | — | 1 | 4.62 |
| CHEMBL424302 | — | — | 1 | 4.60 |
| CHEMBL144632 | — | — | 1 | 4.46 |
| CHEMBL145266 | — | — | 1 | - |
| CHEMBL143108 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356324 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL67535 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL357400 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL144778 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL342792 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL358746 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL144760 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL144589 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL145209 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL144159 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL343887 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL144402 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL144770 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL144842 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL358494 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL144908 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL144791 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL147880 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL279138 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL424302 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL144632 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL145266 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL143108 | — | IC50 | > | 100000.0 | nM | - |