Assay Detail
Functional
CHEMBL689573
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Inhibition of growth of human cytomegalovirus (HCMV) was determined by plaque reduction assay in human lung fibroblast cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cytomegalovirus |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Effect of acyclic pyrimidines related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine on herpesviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.77 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.47 |
| CHEMBL287845 | — | — | 1 | 4.85 |
| CHEMBL38261 | — | — | 1 | 4.00 |
| CHEMBL37840 | — | — | 1 | - |
| CHEMBL37620 | — | — | 1 | - |
| CHEMBL35047 | — | — | 1 | - |
| CHEMBL35150 | — | — | 1 | - |
| CHEMBL38107 | — | — | 1 | - |
| CHEMBL34717 | — | — | 1 | - |
| CHEMBL440106 | — | — | 1 | - |
| CHEMBL288351 | — | — | 1 | - |
| CHEMBL34179 | — | — | 1 | - |
| CHEMBL290107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL287845 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL38261 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL37840 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL37620 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL35047 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL35150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL38107 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL34717 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL440106 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL288351 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL34179 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL290107 | — | IC50 | > | 100000.0 | nM | - |