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Assay Detail

CHEMBL689615

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Reduction of viral load in the cell supernatant.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines.
Polanski J, Zouhiri F, Jeanson L, Desmaële D, d'Angelo J, Mouscadet JF, Gieleciak R, Gasteiger J, Le Bret M.
J Med Chem (2002) 45 : 4647 -4654
PubMed 12361391 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.78 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37869 1 5.92
CHEMBL39092 1 5.89
CHEMBL40170 1 5.52
CHEMBL37845 1 5.17
CHEMBL37431 1 5.05
CHEMBL142246 1 5.00
CHEMBL36640 1 4.92
CHEMBL142412 1 4.92
CHEMBL142829 1 4.82
CHEMBL142358 1 4.70
CHEMBL140065 1 4.70
CHEMBL39301 1 4.52
CHEMBL341951 1 4.52
CHEMBL344803 1 4.30
CHEMBL39883 1 4.30
CHEMBL37139 1 4.27
CHEMBL59548 1 4.10
CHEMBL36586 1 4.10
CHEMBL418613 1 4.02
CHEMBL141946 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37869 IC50 = 1200.0 nM 5.92
CHEMBL39092 IC50 = 1300.0 nM 5.89
CHEMBL40170 IC50 = 3000.0 nM 5.52
CHEMBL37845 IC50 = 6800.0 nM 5.17
CHEMBL37431 IC50 = 9000.0 nM 5.05
CHEMBL142246 IC50 = 10000.0 nM 5.00
CHEMBL36640 IC50 = 12000.0 nM 4.92
CHEMBL142412 IC50 = 12000.0 nM 4.92
CHEMBL142829 IC50 = 15000.0 nM 4.82
CHEMBL142358 IC50 = 20000.0 nM 4.70
CHEMBL140065 IC50 = 20000.0 nM 4.70
CHEMBL39301 IC50 = 30000.0 nM 4.52
CHEMBL341951 IC50 = 30000.0 nM 4.52
CHEMBL344803 IC50 = 50000.0 nM 4.30
CHEMBL39883 IC50 = 50000.0 nM 4.30
CHEMBL37139 IC50 = 54000.0 nM 4.27
CHEMBL59548 IC50 = 80000.0 nM 4.10
CHEMBL36586 IC50 = 80000.0 nM 4.10
CHEMBL418613 IC50 = 95000.0 nM 4.02
CHEMBL141946 IC50 = 110000.0 nM -