Assay Detail
Functional
CHEMBL689645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of HL60 cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.48 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308033 | — | — | 1 | 6.00 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 4.75 |
| CHEMBL311281 | — | — | 1 | 4.40 |
| CHEMBL73766 | — | — | 1 | 4.31 |
| CHEMBL77941 | — | — | 1 | 4.24 |
| CHEMBL76939 | — | — | 1 | 4.22 |
| CHEMBL305910 | — | — | 1 | 4.17 |
| CHEMBL308064 | — | — | 1 | 4.12 |
| CHEMBL78266 | — | — | 1 | 4.10 |
| CHEMBL74486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308033 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL38 | TRETINOIN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL311281 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL73766 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL77941 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL76939 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL305910 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL308064 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL78266 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL74486 | — | IC50 | > | 100000.0 | nM | - |