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Assay Detail

CHEMBL689649

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cytotoxicity against HL60 cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Expert

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Programmed cell death (PCD) associated with the stilbene motif of arotinoids: discovery of novel apoptosis inducer agents possessing activity on multidrug resistant tumor cells.
Simoni D, Roberti M, Invidiata FP, Rondanin R, Baruchello R, Malagutti C, Mazzali A, Rossi M, Grimaudo S, Dusonchet L, Meli M, Raimondi MV, D'Alessandro N, Tolomeo M.
Bioorg Med Chem Lett (2000) 10 : 2669 -2673
PubMed 11128648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.57 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90947 1 5.00
CHEMBL86663 1 5.00
CHEMBL38 TRETINOIN 4.0 1 4.96
CHEMBL90623 1 4.75
CHEMBL90760 1 4.75
CHEMBL327210 1 4.70
CHEMBL91268 1 4.70
CHEMBL90624 1 4.60
CHEMBL92096 1 4.58
CHEMBL315049 1 4.38
CHEMBL275311 1 4.34
CHEMBL88497 1 4.30
CHEMBL88568 1 4.30
CHEMBL89025 1 4.30
CHEMBL91119 1 4.28
CHEMBL88769 1 4.21
CHEMBL91411 1 -
CHEMBL88180 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90947 IC50 = 10000.0 nM 5.00
CHEMBL86663 IC50 = 10000.0 nM 5.00
CHEMBL38 TRETINOIN IC50 = 11000.0 nM 4.96
CHEMBL90623 IC50 = 18000.0 nM 4.75
CHEMBL90760 IC50 = 18000.0 nM 4.75
CHEMBL327210 IC50 = 20000.0 nM 4.70
CHEMBL91268 IC50 = 20000.0 nM 4.70
CHEMBL90624 IC50 = 25000.0 nM 4.60
CHEMBL92096 IC50 = 26000.0 nM 4.58
CHEMBL315049 IC50 = 42000.0 nM 4.38
CHEMBL275311 IC50 = 46000.0 nM 4.34
CHEMBL88497 IC50 = 50000.0 nM 4.30
CHEMBL88568 IC50 = 50000.0 nM 4.30
CHEMBL89025 IC50 = 50000.0 nM 4.30
CHEMBL91119 IC50 = 52000.0 nM 4.28
CHEMBL88769 IC50 = 61000.0 nM 4.21
CHEMBL91411 IC50 > 100000.0 nM -
CHEMBL88180 IC50 > 100000.0 nM -