Assay Detail
Functional
CHEMBL689908
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Concentration resulting in 50% incorporation of [3H]thymidine compared to untreated control cells on H2981 human lung adenocarcinoma cells in the presence of 10 ug/mL Enterobacter cloacae P99 beta-lactamase (ECIbL)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H2981 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-beta-lactamase conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.29 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28740 | — | — | 1 | 6.37 |
| CHEMBL263250 | — | — | 1 | 6.35 |
| CHEMBL406975 | — | — | 1 | 6.33 |
| CHEMBL282534 | — | — | 1 | 6.33 |
| CHEMBL283005 | — | — | 1 | 6.26 |
| CHEMBL282621 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28740 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL263250 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL406975 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL282534 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL283005 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL282621 | — | IC50 | = | 750.0 | nM | 6.12 |