Assay Detail
Functional
CHEMBL689998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The inhibition of compound was determined by reverse transcriptase assay using DNA as template
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.11 | 4.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.16 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.08 |
| CHEMBL566812 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL566812 | — | Ki | = | 84000.0 | nM | 4.08 |