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Assay Detail

CHEMBL690281

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested in vitro for cytotoxicity against the normal human diploid cells (HFF cells).
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HFF
Confidence 1 — Organism
Curated By Intermediate

Target

HFF (CHEMBL614071)
Type CELL-LINE
Organism Homo sapiens

Publication

Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections.
Krawczyk SH, Bernier-Rodriguez M, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB.
J Med Chem (1990) 33 : 3160 -3169
PubMed 2175356 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.44 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101892 SANGIVAMYCIN 1 5.10
CHEMBL99668 TOYOCAMYCIN 1 5.10
CHEMBL3142829 1 4.26
CHEMBL3142828 1 4.18
CHEMBL3142823 1 4.00
CHEMBL3142827 1 4.00
CHEMBL3142826 1 -
CHEMBL3142830 1 -
CHEMBL3142824 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -
CHEMBL3142822 1 -
CHEMBL3142821 1 -
CHEMBL3142825 1 -
CHEMBL182 GANCICLOVIR 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101892 SANGIVAMYCIN IC50 = 8000.0 nM 5.10
CHEMBL99668 TOYOCAMYCIN IC50 = 8000.0 nM 5.10
CHEMBL3142829 IC50 = 55000.0 nM 4.26
CHEMBL3142828 IC50 = 66000.0 nM 4.18
CHEMBL3142823 IC50 = 100000.0 nM 4.00
CHEMBL3142827 IC50 = 100000.0 nM 4.00
CHEMBL3142826 IC50 = 140000.0 nM -
CHEMBL3142830 IC50 = 181000.0 nM -
CHEMBL3142824 IC50 > 100000.0 nM -
CHEMBL184 ACYCLOVIR IC50 > 100000.0 nM -
CHEMBL3142822 IC50 > 100000.0 nM -
CHEMBL3142821 IC50 > 100000.0 nM -
CHEMBL3142825 IC50 > 100000.0 nM -
CHEMBL182 GANCICLOVIR IC50 > 100000.0 nM -