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Assay Detail

CHEMBL690500

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory concentration required against human colorectal adenocarcinoma HT-29 cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Intermediate

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and anticancer effect of chrysin derivatives.
Zheng X, Meng WD, Xu YY, Cao JG, Qing FL.
Bioorg Med Chem Lett (2003) 13 : 881 -884
PubMed 12617913 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.56 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169645 1 5.72
CHEMBL275391 CHRYSIN DIMETHYL ETHER 1 5.70
CHEMBL171039 1 5.64
CHEMBL368559 1 5.64
CHEMBL353368 1 5.64
CHEMBL353283 1 5.58
CHEMBL367505 CHRYSIN DIACETATE 1 5.58
CHEMBL262919 1 5.54
CHEMBL171821 1 5.52
CHEMBL117 CHRYSIN 1 5.51
CHEMBL353729 1 5.42
CHEMBL55942 1 5.40
CHEMBL352508 1 5.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169645 IC50 = 1900.0 nM 5.72
CHEMBL275391 CHRYSIN DIMETHYL ETHER IC50 = 2000.0 nM 5.70
CHEMBL171039 IC50 = 2300.0 nM 5.64
CHEMBL368559 IC50 = 2300.0 nM 5.64
CHEMBL353368 IC50 = 2300.0 nM 5.64
CHEMBL353283 IC50 = 2600.0 nM 5.58
CHEMBL367505 CHRYSIN DIACETATE IC50 = 2600.0 nM 5.58
CHEMBL262919 IC50 = 2900.0 nM 5.54
CHEMBL171821 IC50 = 3000.0 nM 5.52
CHEMBL117 CHRYSIN IC50 = 3100.0 nM 5.51
CHEMBL353729 IC50 = 3800.0 nM 5.42
CHEMBL55942 IC50 = 4000.0 nM 5.40
CHEMBL352508 IC50 = 4400.0 nM 5.36