Assay Detail
Functional
CHEMBL690538
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Evaluated for the inhibitory concentration required to cause growth inhibition of H322M cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H322M |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.45 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87938 | — | — | 1 | 4.85 |
| CHEMBL85702 | — | — | 1 | 4.60 |
| CHEMBL87240 | — | — | 1 | 4.50 |
| CHEMBL87769 | — | — | 1 | 4.43 |
| CHEMBL86892 | — | — | 1 | 4.38 |
| CHEMBL84852 | — | — | 1 | 4.38 |
| CHEMBL316041 | — | — | 1 | 4.26 |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87938 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL85702 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL87240 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL87769 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL86892 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL84852 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL316041 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL513 | CARMUSTINE | IC50 | = | 60000.0 | nM | 4.22 |