Assay Detail
Functional
CHEMBL690682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration required to inhibit Epstein-Barr virus (EBV) replication in H-1 cell line
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human gammaherpesvirus 4 |
| Cell Type | H-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 4.87 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155623 | — | — | 1 | 5.32 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 5.16 |
| CHEMBL157102 | — | — | 1 | 4.80 |
| CHEMBL152418 | — | — | 1 | 4.79 |
| CHEMBL2111211 | — | — | 1 | 4.79 |
| CHEMBL2111213 | — | — | 1 | 4.73 |
| CHEMBL421982 | — | — | 1 | 4.72 |
| CHEMBL154409 | — | — | 1 | 4.68 |
| CHEMBL152780 | — | — | 1 | - |
| CHEMBL2111212 | — | — | 1 | - |
| CHEMBL513554 | — | — | 1 | - |
| CHEMBL357549 | — | — | 1 | - |
| CHEMBL359127 | — | — | 1 | - |
| CHEMBL152335 | — | — | 1 | - |
| CHEMBL347817 | — | — | 1 | - |
| CHEMBL151794 | — | — | 1 | - |
| CHEMBL153255 | — | — | 1 | - |
| CHEMBL345346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155623 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL265948 | FILOCICLOVIR | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL157102 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL152418 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL2111211 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL2111213 | — | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL421982 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL154409 | — | EC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL152780 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2111212 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL513554 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL357549 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL359127 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL152335 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL347817 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL151794 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL153255 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL345346 | — | EC50 | > | 20000.0 | nM | - |