Assay Detail
Toxicity
CHEMBL690698
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Toxicity in HUVEC cell lysates.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Subcellular | Lysate |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.22 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324158 | — | — | 1 | 4.47 |
| CHEMBL118518 | — | — | 1 | 4.26 |
| CHEMBL115815 | — | — | 1 | 4.17 |
| CHEMBL116089 | — | — | 1 | 4.15 |
| CHEMBL117453 | — | — | 1 | 4.04 |
| CHEMBL119091 | — | — | 1 | - |
| CHEMBL116070 | — | — | 1 | - |
| CHEMBL117571 | — | — | 1 | - |
| CHEMBL116363 | — | — | 1 | - |
| CHEMBL119886 | — | — | 1 | - |
| CHEMBL115960 | — | — | 1 | - |
| CHEMBL119732 | — | — | 1 | - |
| CHEMBL326271 | — | — | 1 | - |
| CHEMBL268567 | — | — | 1 | - |
| CHEMBL119733 | — | — | 1 | - |
| CHEMBL325184 | — | — | 1 | - |
| CHEMBL119861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324158 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL118518 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL115815 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL116089 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL117453 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL119091 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL116070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL117571 | — | IC50 | > | 87000.0 | nM | - |
| CHEMBL116363 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL119886 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115960 | — | IC50 | > | 10.0 | ug.mL-1 | - |
| CHEMBL119732 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL326271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268567 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL119733 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325184 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL119861 | — | IC50 | > | 100000.0 | nM | - |