Assay Detail
Functional
CHEMBL690708
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Cytotoxicity against human nasopharyngeal carcinoma HONE-1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HONE1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.02 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336442 | — | — | 1 | 7.22 |
| CHEMBL341709 | — | — | 1 | 7.16 |
| CHEMBL343222 | — | — | 1 | 6.89 |
| CHEMBL321473 | — | — | 1 | 6.51 |
| CHEMBL343088 | — | — | 1 | 6.10 |
| CHEMBL139229 | — | — | 1 | 6.07 |
| CHEMBL344053 | — | — | 1 | 5.62 |
| CHEMBL343337 | — | — | 1 | 4.41 |
| CHEMBL335568 | — | — | 1 | 4.19 |
| CHEMBL1161218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336442 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL341709 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL343222 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL321473 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL343088 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL139229 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL344053 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL343337 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL335568 | — | IC50 | = | 63900.0 | nM | 4.19 |
| CHEMBL1161218 | — | IC50 | > | 100000.0 | nM | - |