Assay Detail

CHEMBL690778

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against NCI tumor panel, HL-60(TB) leukemia cell line

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

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Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Intermediate

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity.

Wang Y, Yuan H, Ye W, Wright SC, Wang H, Larrick JW.
J Med Chem (2000) 43 : 1541 -1549
PubMed 10780911 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.85	8.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL38957	—	—	1	8.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL38957	—	IC50	=	1.4	nM	8.85