Assay Detail
Functional
CHEMBL690865
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Inhibition of mitogenesis in human aortic smooth muscle cells (HASMC)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HASMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.70 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104266 | — | — | 1 | 6.87 |
| CHEMBL105322 | — | — | 1 | 6.79 |
| CHEMBL104466 | — | — | 1 | 6.45 |
| CHEMBL107390 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104266 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL105322 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL104466 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL107390 | — | IC50 | > | 10000.0 | nM | - |