Compound Detail
CHEMBL104266
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Basic Information
| ChEMBL ID | CHEMBL104266 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZIKJGFZRXYVGMK-WDMOLILDSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
2.61
ALogP
6
HBA
2
HBD
76.5
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
| HASMC CHEMBL614150 | IC50 | 6.87 | 6.87 | 134.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor | IC50 | = | 18.0 | nM | 7.75 | Inhibition of Platelet-derived growth factor receptor | 12941342 |
| HASMC | IC50 | = | 134.0 | nM | 6.87 | Inhibition of mitogenesis in human aortic smooth muscle cells (HASMC) | 12941342 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12941342 | 10.1016/s0960-894x(03)00655-3 | Platelet-derived growth factor receptor | 2 |
| 12941342 | 10.1016/s0960-894x(03)00655-3 | HASMC | 1 |
Data from ChEMBL 36 via Core Engine