Assay Detail
Binding
CHEMBL765709
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Inhibition of Platelet-derived growth factor receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2095189) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.03 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105364 | — | — | 1 | 8.22 |
| CHEMBL104266 | — | — | 1 | 7.75 |
| CHEMBL105322 | — | — | 1 | 7.62 |
| CHEMBL2111669 | — | — | 1 | 7.55 |
| CHEMBL107677 | — | — | 1 | 7.39 |
| CHEMBL321276 | — | — | 1 | 7.31 |
| CHEMBL104074 | — | — | 1 | 7.17 |
| CHEMBL104466 | — | — | 1 | 7.12 |
| CHEMBL107402 | — | — | 1 | 6.91 |
| CHEMBL2112462 | — | — | 1 | 6.46 |
| CHEMBL66643 | — | — | 1 | 6.34 |
| CHEMBL106878 | — | — | 1 | 6.03 |
| CHEMBL104581 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105364 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL104266 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL105322 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2111669 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL107677 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL321276 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL104074 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL104466 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL107402 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL2112462 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL66643 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL106878 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL104581 | — | IC50 | = | 3100.0 | nM | 5.51 |