Assay Detail
Functional
CHEMBL690997
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Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.96 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL902 | FAMOTIDINE | 4.0 | 1 | 6.52 |
| CHEMBL556048 | — | — | 1 | 5.89 |
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL902 | FAMOTIDINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL556048 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1790041 | RANITIDINE | IC50 | = | 3400.0 | nM | 5.47 |