Histamine H2 receptor · SINGLE PROTEIN · Cavia porcellus
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As of 2026-09-14Protein identity stays anchored to UniProt P47747. Use UniProt P47747 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P47747 as the stable identity anchor, then attach disease evidence before program review.
Histamine H2 receptor
Review this target as Histamine H2 receptor, mapped to UniProt P47747. Sequence length is 359 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H2 receptor as ChEMBL target CHEMBL2882, mapped to UniProt P47747. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histamine H2 receptor is the right protein anchor across sources, using UniProt P47747 as the stable mapping.
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| Preferred Name | Histamine H2 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
| UniProt | P47747 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H2 receptor |
| UniProt Accession | P47747 |
| Component Type | Protein |
| Sequence Length | 359 aa |
Histamine H2 receptor
Review this target as Histamine H2 receptor, mapped to UniProt P47747. Sequence length is 359 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2165630 | 9.61 | EC50 | 0.2455 | Preclinical |
| CHEMBL2165632 | 9.41 | EC50 | 0.39 | Preclinical |
| CHEMBL2165628 | 9.29 | EC50 | 0.51 | Preclinical |
| CHEMBL2165642 | 9.22 | EC50 | 0.6026 | Preclinical |
| CHEMBL72193 | 9.15 | Ki | 0.7079 | Preclinical |
| CHEMBL2165631 | 9.08 | EC50 | 0.8318 | Preclinical |
| CHEMBL5184911 | 9.04 | EC50 | 0.912 | Preclinical |
| CHEMBL5206565 | 8.88 | EC50 | 1.318 | Preclinical |
| CHEMBL2165636 | 8.87 | EC50 | 1.349 | Preclinical |
| CHEMBL5200771 | 8.64 | EC50 | 2.291 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 133 | 146 | 6.8 |
| assay format | 36 | 36 | 5.6 |
| cell-based format | 7 | 40 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 35 | 54 | 5.2 |
| single protein format | 24 | 41 | 6.5 |
| cell-based format | 3 | 5 | 7.5 |
| cell membrane format | 2 | 8 | 8.0 |