Compound Detail
CHEMBL2165631
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Cc1nc(N)sc1CCCN/C(N)=N/C(=O)CCCCCCCC(=O)/N=C(\N)NCCCc1sc(N)nc1C
Basic Information
| ChEMBL ID | CHEMBL2165631 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FVDUUTISXASABV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
578.8
MW (Da)
2.54
ALogP
8
HBA
6
HBD
212.8
PSA (Ų)
0.10
QED
2
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 9.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H2 receptor CHEMBL2882 | EC50 | 9.08 | 8.82 | 0.8 | 2 |
| Histamine H2 receptor CHEMBL1941 | EC50 | 7.35 | 7.35 | 44.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H2 receptor | EC50 | = | 0.8318 | nM | 9.08 | Agonist activity at H2R in spontaneously beating guinea pig right atrium assesse... | 22216892 |
| Histamine H2 receptor | EC50 | = | 2.754 | nM | 8.56 | Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to ... | 22216892 |
| Histamine H2 receptor | EC50 | = | 44.67 | nM | 7.35 | Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM... | 22216892 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22216892 | 10.1021/jm201128q | Histamine H2 receptor | 9 |
| 22216892 | 10.1021/jm201128q | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine