Assay Detail
Functional
CHEMBL691052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against wild type strain,HIV104pre.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.68 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.60 |
| CHEMBL49002 | — | — | 1 | 7.82 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.72 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.70 |
| CHEMBL299578 | — | — | 1 | 7.51 |
| CHEMBL50945 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL49002 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL299578 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL50945 | — | IC50 | = | 180.0 | nM | 6.75 |