Assay Detail
Functional
CHEMBL691099
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In vitro antiviral activity against NNRTI-resistant R88703R-IIIB (Y181C) HIV-1 variant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | human immunodeficiency virus type1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
(-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280752 | — | — | 1 | 6.77 |
| CHEMBL280541 | — | — | 1 | 6.77 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 6.00 |
| CHEMBL268871 | L-697661 | — | 1 | 5.11 |
| CHEMBL283861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280752 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL280541 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL268871 | L-697661 | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL283861 | — | IC50 | > | 10000.0 | nM | - |