Assay Detail
Functional
CHEMBL691111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1.
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.98 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276108 | — | — | 1 | 8.57 |
| CHEMBL119160 | — | — | 1 | 8.30 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL113760 | — | — | 1 | 8.11 |
| CHEMBL16684 | — | — | 1 | 7.89 |
| CHEMBL429778 | — | — | 1 | 7.85 |
| CHEMBL116577 | — | — | 1 | 7.37 |
| CHEMBL118030 | — | — | 1 | 7.23 |
| CHEMBL275187 | — | — | 1 | 7.20 |
| CHEMBL324378 | — | — | 1 | 6.96 |
| CHEMBL279360 | — | — | 1 | 6.92 |
| CHEMBL118071 | — | — | 1 | 6.66 |
| CHEMBL275599 | — | — | 1 | 6.58 |
| CHEMBL32457 | — | — | 1 | 6.01 |
| CHEMBL116501 | — | — | 1 | 5.89 |
| CHEMBL274705 | — | — | 1 | 5.60 |
| CHEMBL16535 | — | — | 1 | 5.58 |
| CHEMBL417626 | — | — | 1 | 5.57 |
| CHEMBL278905 | — | — | 1 | 5.48 |
| CHEMBL16968 | — | — | 1 | 5.47 |
| CHEMBL280068 | — | — | 1 | 5.24 |
| CHEMBL31871 | HEPT | — | 1 | 5.16 |
| CHEMBL117433 | — | — | 1 | 5.14 |
| CHEMBL16763 | — | — | 1 | 5.10 |
| CHEMBL117665 | — | — | 1 | 5.00 |
| CHEMBL16628 | — | — | 1 | 5.00 |
| CHEMBL279579 | — | — | 1 | 5.00 |
| CHEMBL276058 | — | — | 1 | 4.92 |
| CHEMBL418726 | — | — | 1 | 4.89 |
| CHEMBL278944 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276108 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL119160 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL113760 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL16684 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL429778 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL116577 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL118030 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL275187 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL324378 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL279360 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL118071 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL275599 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL32457 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL116501 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL274705 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL16535 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL417626 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL278905 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL16968 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL280068 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL31871 | HEPT | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL117433 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL16763 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL279579 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL16628 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL117665 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL276058 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL418726 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL278944 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL17097 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL16824 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL440274 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL280279 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL279637 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL274458 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL118078 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL330759 | — | EC50 | > | 306000.0 | nM | - |
| CHEMBL116471 | — | EC50 | > | 292000.0 | nM | - |
| CHEMBL117196 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL325458 | — | EC50 | > | 6600.0 | nM | - |
| CHEMBL117653 | — | EC50 | > | 18000.0 | nM | - |
| CHEMBL119904 | — | EC50 | > | 352000.0 | nM | - |
| CHEMBL16686 | — | EC50 | = | 220000.0 | nM | - |
| CHEMBL116799 | — | EC50 | > | 190000.0 | nM | - |
| CHEMBL116556 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL116566 | — | EC50 | > | 130000.0 | nM | - |
| CHEMBL116695 | — | EC50 | > | 110000.0 | nM | - |
| CHEMBL117945 | — | EC50 | > | 277000.0 | nM | - |
| CHEMBL114560 | — | EC50 | > | 250000.0 | nM | - |