Assay Detail
Functional
CHEMBL691298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in human prostate cancer HTB-81 cells using MTS assay.
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTB-81 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity of 4-amino-5-oxopyrido[2,3-d]pyrimidine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.25 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99668 | TOYOCAMYCIN | — | 1 | 7.92 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.24 |
| CHEMBL2092792 | — | — | 2 | 7.22 |
| CHEMBL610414 | — | — | 1 | 6.17 |
| CHEMBL610978 | — | — | 1 | 6.14 |
| CHEMBL1790865 | — | — | 1 | 5.58 |
| CHEMBL2112131 | — | — | 1 | 5.41 |
| CHEMBL610697 | — | — | 1 | 5.35 |
| CHEMBL1794856 | — | — | 1 | 5.21 |
| CHEMBL609813 | — | — | 1 | 5.14 |
| CHEMBL1794858 | — | — | 1 | 5.00 |
| CHEMBL1794857 | — | — | 1 | 4.76 |
| CHEMBL608345 | — | — | 1 | 4.71 |
| CHEMBL611894 | — | — | 1 | 4.69 |
| CHEMBL607770 | — | — | 1 | 4.66 |
| CHEMBL2112133 | — | — | 1 | 4.58 |
| CHEMBL608339 | — | — | 1 | 4.53 |
| CHEMBL1790863 | — | — | 1 | 4.51 |
| CHEMBL607768 | — | — | 1 | 4.47 |
| CHEMBL610123 | — | — | 1 | 4.45 |
| CHEMBL609226 | — | — | 1 | 4.43 |
| CHEMBL123358 | — | — | 1 | 4.36 |
| CHEMBL608634 | — | — | 1 | 4.33 |
| CHEMBL122927 | — | — | 1 | - |
| CHEMBL3084720 | — | — | 1 | - |
| CHEMBL330817 | — | — | 1 | - |
| CHEMBL609234 | — | — | 1 | - |
| CHEMBL2112132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99668 | TOYOCAMYCIN | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL178 | DAUNORUBICIN | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2092792 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL610414 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL610978 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1790865 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2112131 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL610697 | — | EC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL1794856 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL609813 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1794858 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1794857 | — | EC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL608345 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL611894 | — | EC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL607770 | — | EC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL2112133 | — | EC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL608339 | — | EC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL1790863 | — | EC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL607768 | — | EC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL610123 | — | EC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL609226 | — | EC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL123358 | — | EC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL608634 | — | EC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL122927 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3084720 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL330817 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2092792 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL609234 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2112132 | — | EC50 | > | 100000.0 | nM | - |